[摘要] 目的 观察脑血管畸形(CVM)患者血管内皮生长因子(VEGF)蛋白的表达情况,探讨VEGF蛋白在脑血管畸形患者中的表达特点与意义。方法 应用免疫组织化学方法检测62例脑血管畸形患者标本中VEGF蛋白的表达。结果 62例脑血管畸形标本中,VEGF蛋白在畸形血管中阳性表达率为72.6%(45/62),畸形血管周围正常脑组织中血管的VEGF蛋白阳性表达率为51.6%(32/62),两者比较有差异(P75%为4分。根据染色强度与阳性细胞数得分之积分为4级,即(-)为0分,弱阳性(+)为1～2分,阳性(++)为3～4分,强阳性(+++)为5～6分。将A×B作为其染色的计数,只有A×B > 3 分才算免疫反应阳性,并按乘积分数将染色结果分为4 个等级:-(0～2 分)、+(3～5 分)、+ +(6～8分)和+ + +(9～12分)。
1.4 统计学方法
统计学处理应用SPSS10.0软件进行χ2检验和Fisher确切概率法,P 本文为全文原貌 未安装PDF浏览器用户请先下载安装 原版全文 [参考文献]
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(收稿日期:2010-03-01)
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